An open educational resource by eLearningFRCPath Last updated: March 2026
✦ Free & Open Access Updated March 2026 WHO 5th Edition Aligned

199 High-Yield NEET SS Pathology MCQs
With Answers & Concept Explanations

A comprehensive, exam-pattern question bank covering 13 major pathology systems. Designed for NEET SS Pathology, INI-SS DM Histopathology, and FRCPath Part 1 candidates. Every question tests mechanism, morphology, and clinico-pathological correlation — with detailed explanations, not just answers.

By Dr. Akshay Bali & Dr. Maitrayee Roy · Practising Pathologists · eLearningFRCPath

Published January 2026 · Last updated March 2026 · 2026 Edition

199
MCQs
13
Systems
100%
Free
3-in-1
NEET SS · INI-SS · FRCPath

For Educators & Students About This Resource

This PDF Includes

  • 199 original MCQs with detailed concept explanations
  • Questions aligned with WHO Classification of Tumours, 5th Edition
  • Coverage across 13 pathology systems (see full list below)
  • Concept-based approach testing mechanism and morphology
  • Explanations for correct answers and why distractors are wrong

Designed For

  • NEET SS Pathology candidates (India)
  • INI-SS DM Histopathology aspirants
  • FRCPath Part 1 candidates (UK & international)
  • Pathology residents seeking exam-quality practice
  • Faculty looking for teaching question banks
Open for educational use. You are free to share, distribute, or reference this resource for educational and non-commercial purposes. We encourage educators to link to this page so students always access the latest edition.

Direct download — no email, no login, no paywall

Download 199 MCQs — Free PDF

PDF · 2026 Edition · No registration required

13 Pathology Systems Covered

Jump to any system. Each section tests the highest-yield topics examiners favour.

01

Thyroid Pathology

BRAF V600E, RAS mutations, NIFTP, TERT promoter mutations, papillary carcinoma variants, calcitonin-negative MTC, WHO 5th Edition updates.

02

Breast Pathology

Invasive carcinoma subtypes, molecular classification (Luminal A/B, HER2, Basal), BRCA1/2, triple-negative breast cancer, prognostic markers, DCIS.

03

Hepatobiliary Pathology

HCC, cholangiocarcinoma, autoimmune hepatitis, PBC, PSC, Wilson's disease, hepatic steatosis patterns, viral hepatitis grading.

04

Pancreatic Pathology

IPMN, MCN, SPN, ductal adenocarcinoma, acinar cell carcinoma, PanIN, neuroendocrine tumours, WHO grading system.

05

Dermatopathology

BCC, SCC, melanoma staging, Breslow thickness, dermatofibrosarcoma protuberans, Merkel cell carcinoma, inflammatory dermatoses.

06

Haematopathology

Leukaemia classification, lymphoma subtypes, tumour lysis syndrome, myeloproliferative disorders, plasma cell neoplasms, bone marrow pathology.

07

Gastrointestinal Pathology

GIST, colorectal carcinoma, FAP, juvenile polyposis, IBD patterns, carcinoma of unknown primary, GI NET grading.

08

Genitourinary Pathology

RCC subtypes, urothelial carcinoma, prostate carcinoma Gleason grading, Wilms tumour, testicular germ cell tumours.

09

Gynaecological Pathology

Endometrial carcinoma types, cervical SIL, ovarian tumour classification, gestational trophoblastic disease, LVI significance.

10

Pulmonary Pathology

UIP pattern, DAD, hypersensitivity pneumonitis, lung adenocarcinoma classification, carcinoid tumours, EGFR mutation significance.

11

Neuropathology

WHO 2021 CNS tumour classification, IDH mutation, TERT promoter, 1p/19q co-deletion, glioblastoma, medulloblastoma molecular groups.

12

Molecular Pathology

IHC markers, EGFR, KRAS, BRAF, NTRK fusions, next-generation sequencing, predictive vs prognostic biomarkers.

13

Clinical Governance

Audit cycles, quality indicators in pathology labs, clinical governance frameworks — high-yield for NEET SS and FRCPath examinations.

Sample Questions

Four real questions from the free PDF. Every question tests clinical reasoning and mechanism — not rote recall.

Thyroid Pathology · Question 1

Which molecular alteration is most commonly associated with invasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC)?

  • A. BRAF V600E mutation
  • B. RAS mutation (HRAS/NRAS/KRAS) ✓
  • C. RET/PTC rearrangement
  • D. TERT promoter mutation
Concept: EFVPTC and NIFTP are characterised by high-frequency RAS mutations (particularly NRAS), similar to follicular adenoma. BRAF V600E is the hallmark of classical and tall-cell PTC, not EFVPTC.
Thyroid Pathology · Question 4

A 35-year-old female with a thyroid tumour is found to have a TERT promoter mutation. What is the most likely implication?

  • A. Indolent course with excellent prognosis
  • B. Resistance to radioactive iodine ✓
  • C. Association with familial medullary carcinoma
  • D. No impact on prognosis
Concept: TERT promoter mutations indicate more aggressive tumour behaviour and are associated with resistance to radioactive iodine therapy in papillary thyroid carcinoma — a high-yield examiner favourite.
Thyroid Pathology · Question 3

Congo red stain is positive, but IHC for calcitonin is negative. Which stain would be most helpful next to confirm medullary thyroid carcinoma?

  • A. Thyroglobulin
  • B. Chromogranin A ✓
  • C. TTF-1
  • D. CK7
Concept: Calcitonin-negative MTC is a rare variant. Chromogranin A confirms the neuroendocrine nature of the tumour when calcitonin IHC fails — testing integrated diagnostic reasoning.
Thyroid Pathology · Question 2

A thyroid tumour shows cribriform areas with spindle-cell morules; IHC shows nuclear β-catenin and ER positivity. Which molecular alteration is most commonly associated?

  • A. BRAF V600E mutation
  • B. Germline APC mutation ✓
  • C. RET/PTC1 fusion
  • D. HRAS mutation
Concept: Cribriform-morular variant of PTC with nuclear β-catenin is associated with germline APC mutation (FAP). A classic morphology-to-molecular correlation question — very high yield for NEET SS.

This is a preview of 4 questions. The full PDF contains 199 across all 13 systems.

Recommended Study Strategy

A 3-pass approach recommended by Dr. Akshay Bali for maximum retention.

1

First Pass — Attempt Blind

Go through all 199 MCQs without reading the answers. Mark questions you're unsure about. This reveals your genuine weak areas — which is the whole point of the first pass.

2

Second Pass — Read Explanations

For every question you got wrong or marked, read the explanation carefully. The explanations tell you why the correct answer is right and why the distractors are wrong — that's where real learning happens.

3

Final Pass — Rapid Revision

In the final weeks before NEET SS or INI-SS, use the PDF for rapid self-assessment. Re-attempt flagged questions. By now, your accuracy should visibly improve across all 13 systems.

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Download All 199 MCQs — Free PDF

PDF · 2026 Edition · No registration required

Share or Cite This Resource

Teaching a pathology class? Running a study group? You can link to or embed this resource freely.

Direct link (recommended):

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Academic citation:

Bali, A., Roy, M. (2026). 199 High-Yield NEET SS Pathology MCQs with Answers
& Concept Explanations
(2026 ed.). eLearningFRCPath.
Available at: https://www.elearningfrcpath.com/pathology-mcq-pdf

This resource is free for educational and non-commercial use. For the latest edition, always link to this page rather than directly to the PDF file.

Frequently Asked Questions

Common questions about the 199 MCQ PDF resource.

Is the 199 MCQ PDF really free — no registration needed?
Yes. The PDF is 100% free with no email capture, login, or paywall. You can download it directly and start studying immediately. We believe every pathology candidate deserves access to quality practice material regardless of their financial situation.
Which exams does this pathology MCQ PDF cover?
The 199 MCQs are designed for NEET SS Pathology, INI-SS DM Histopathology, and FRCPath Part 1. The questions test mechanism, morphology, and clinico-pathological correlation — topics that are tested across all three examinations. The overlap in core pathology knowledge makes this a genuinely useful 3-in-1 resource.
Is this aligned with the WHO 5th Edition classification?
Yes. All questions and explanations reflect the WHO Classification of Tumours, 5th Edition (2019–2024 volumes), including updated grading systems, molecular markers, and nomenclature changes. This is the classification being tested in current examinations.
Who authored this resource?
The 199 MCQs were compiled by Dr. Akshay Bali and Dr. Maitrayee Roy, practising pathologists with extensive experience in exam-oriented pathology education. They are the faculty behind eLearningFRCPath, which has been training NEET SS and FRCPath candidates since its inception.
Can I share this PDF with my students or on my college website?
Absolutely. You are free to share, distribute, or reference this resource for educational and non-commercial purposes. We encourage educators to link to this page (rather than the PDF directly) so students always access the latest updated edition. You can find a copy-paste embed snippet in the "Share or Cite" section above.
How is this different from other pathology MCQ PDFs available online?
Most free pathology MCQs test rote recall. These 199 questions are concept-based — they test mechanism, molecular correlations, and clinico-pathological reasoning. Every question includes a full explanation of why the correct answer is right and why each distractor is wrong. They are written by practising pathologists, not generated by AI or copied from textbooks.

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